2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS: 660867-80-1)

2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a crystalline compound with a molecular weight of approximately 332.4 g/mol. It has low solubility in water but is more soluble in organic solvents like DMF and DMSO. The compound is reactive towards nucleophiles and can participate in various organic transformations, such as Suzuki coupling reactions. It is stable under normal laboratory conditions but should be stored away from moisture and heat.

2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is typically synthesized via the reaction of 2-methylpyridine with 1,3,2-dioxaborine in the presence of a base such as potassium carbonate and a palladium catalyst, such as Pd(PPh3)4. The method provides good yield and selectivity, making it a common approach for the synthesis of this compound in academic and industrial settings.

2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and polymers due to its excellent reactivity in cross-coupling reactions. Additionally, it finds applications in the development of sensors and semiconductors, where its unique chemical properties are leveraged.

When handling 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is essential to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials and rinsing with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and disposal.