3-Bromo-1H-pyrazolo[4,3-c]pyridine(CAS: 633328-88-8)

3-Bromo-1H-pyrazolo[4,3-c]pyridine is a crystalline solid with a molecular weight of approximately 237.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like DMSO and DMF. This compound shows moderate reactivity, particularly towards nucleophiles, and exhibits good stability under normal storage conditions.

3-Bromo-1H-pyrazolo[4,3-c]pyridine is commonly synthesized via bromination of 1H-pyrazolo[4,3-c]pyridine using N-bromosuccinimide (NBS) in the presence of a peroxide initiator like benzoyl peroxide. The reaction yields the desired product with good selectivity and moderate yield.

3-Bromo-1H-pyrazolo[4,3-c]pyridine finds applications in pharmaceuticals, particularly as a precursor for drug synthesis. It is also used in the preparation of sensors and as a ligand in coordination chemistry, though its uses in other industries are more limited.

When handling 3-Bromo-1H-pyrazolo[4,3-c]pyridine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood, and ensure proper spill cleanup procedures are followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.