2-(Trifluoromethyl)nicotinic acid(CAS: 131747-43-8)

2-(Trifluoromethyl)nicotinic acid is a white crystalline solid with a molecular weight of approximately 242.12 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetonitrile. This compound is highly reactive, particularly in nucleophilic substitution reactions. It forms stable crystalline forms suitable for various applications in pharmaceuticals and materials science.

2-(Trifluoromethyl)nicotinic acid can be synthesized through the trifluoromethylation of nicotinic acid using reagents such as triflic anhydride. Common methods include nucleophilic substitution reactions in the presence of appropriate bases. The synthesis typically yields a high percentage of the desired product with good selectivity.

2-(Trifluoromethyl)nicotinic acid is utilized in various industries, particularly in pharmaceuticals for its role as a precursor in the synthesis of biologically active compounds. It also finds applications in the preparation of materials for sensors and advanced polymers due to its unique chemical properties.

When handling 2-(Trifluoromethyl)nicotinic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated environment or a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Refer to the Safety Data Sheet (SDS) for specific handling guidelines and emergency procedures.