(S)-Alogliptin(CAS: 1108732-05-3)

(S)-Alogliptin is a white to off-white solid with a molecular weight of approximately 332.3 g/mol. It has low water solubility, making it poorly soluble in water and more soluble in organic solvents like ethanol and methanol. Chemically, it is reactive towards reducing agents and can undergo hydrolysis under basic conditions. It is a potent inhibitor of dipeptidyl peptidase-4 (DPP-4) with high specificity and selectivity.

(S)-Alogliptin is typically synthesized through asymmetric synthesis. The key step involves the use of chiral auxiliaries and organocatalysts to achieve high enantiomeric excess. The synthetic route involves a series of reactions including alkylation, reduction, and chemical modification to introduce the necessary functional groups and chirality. The overall process yields (S)-Alogliptin with high purity and selectivity.

(S)-Alogliptin is primarily used in the pharmaceutical industry, where it serves as an active pharmaceutical ingredient (API) in the treatment of type 2 diabetes. It is also of interest in academic research for studying DPP-4 inhibitors and their mechanisms of action. While it has potential applications in other fields, its primary use remains in the development of drugs for diabetes management.

When handling (S)-Alogliptin, it is essential to use personal protective equipment (PPE) such as gloves and safety glasses. It should be stored in a cool, dry place away from direct sunlight. In case of a spill, use appropriate absorbent materials and follow local waste disposal regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information to ensure safe laboratory practice.