1-benzofuran-2-carboxylic acid(CAS: 496-41-3)

1-Benzofuran-2-carboxylic acid (CAS: 496-41-3) is a crystalline solid with a molecular weight of approximately 184.17 g/mol. It has a pKa of about 4.3 and is slightly soluble in water. Chemically, it is reactive towards nucleophiles and can undergo esterification and amide formation reactions. It is also prone to hydrolysis under basic conditions.

1-Benzofuran-2-carboxylic acid (CAS: 496-41-3) can be synthesized by the condensation of benzoic acid and furan under acidic conditions. Alternatively, it can be prepared by the oxidation of 2-furanmethanol using potassium permanganate. These methods yield a product with a purity of over 95%.

1-Benzofuran-2-carboxylic acid (CAS: 496-41-3) is used in various industries, including pharmaceuticals for the synthesis of medicinal compounds, polymers for the production of resins and coatings, and sensors for detecting organic pollutants. It also has applications in the development of semiconductors and as a precursor in organic synthesis.

When handling 1-Benzofuran-2-carboxylic acid (CAS: 496-41-3), wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a well-ventilated area away from heat sources. Use a fume hood during operations. In case of spill, use appropriate absorbent materials and dispose of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.