1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride(CAS: 94240-17-2)

1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride is a white crystalline solid with a molecular weight of approximately 265.7. It has a pKa of about 3 and is moderately soluble in water and ethanol. It is reactive towards bases and nucleophiles. This compound displays good solubility in organic solvents such as methanol and acetone. It is used as a precursor in various chemical syntheses.

1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride is typically synthesized via the condensation of 3-hydroxybenzaldehyde with methylamine followed by acidification with hydrochloric acid. The reaction is catalyzed by a strong acid, with a yield of up to 90% and excellent selectivity.

1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride is used in the pharmaceutical industry for the synthesis of certain drugs. It is also applied in the polymer industry to enhance the functionality of polymers. Additionally, it is used in the production of sensors and semiconductors for its unique chemical properties.

When handling 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a laboratory coat. The compound should be used in a well-ventilated area or a fume hood. Spills should be cleaned up carefully, and the area should be well-ventilated before cleanup. Always refer to the Safety Data Sheet (SDS) for detailed safety information.