5-chloro-6-hydroxy-pyridine-3-carbaldehyde(CAS: 627501-18-2)

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) is a crystalline solid with a molecular weight of approximately 210.01 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive, particularly towards nucleophiles and bases, making it useful in various chemical transformations. It exhibits weak basicity and acidity, which can influence its reactivity in different synthetic contexts.

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) can be synthesized through the condensation of 5-chloro-6-hydroxy-pyridine with acetaldehyde, often in the presence of a catalytic amount of acid. The reaction provides good yield and selectivity, with the use of common reagents like sulfuric acid or hydrochloric acid facilitating the process.

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) is primarily used in the pharmaceutical and chemical industries for the development of intermediate compounds. It finds applications in the synthesis of drugs and other organic molecules due to its functional groups, which can be further modified to create various chemical entities.

When handling 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, well-ventilated area, and handled under a fume hood to minimize inhalation risk. In case of spills, immediate cleanup should be performed following standard laboratory safety procedures, and a Material Safety Data Sheet (MSDS) should be readily available for reference.