5-chloro-6-hydroxy-pyridine-3-carbaldehyde

Basic Information

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CAS Number

627501-18-2

Molecular Formula

C6H4ClNO2

Molecular Weight

157.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Density

1.43

SMILES

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C1=C(C(=O)NC=C1C=O)Cl

InChI

InChI=1S/C6H4ClNO2/c7-5-1-4(3-9)2-8-6(5)10/h1-3H,(H,8,10)

InChIKey

FGMJOLYLUIKTGP-UHFFFAOYSA-N

LogP

1.2531

Topological Polar Surface Area

50.190000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

242

Synonyms & References

English

AS-8518
SCHEMBL4325787
5-chloro-6-hydroxynicotinaldehyde
5-chloro-6-hydroxy-pyridine-3-carbaldehyde
3-CHLORO-5-FORMYL-2-HYDROXYPYRIDINE
FT-0756107
CB-0749
MFCD09607922
AB20957
A8673
DTXSID60640007
5-chloro-6-oxo-1H-pyridine-3-carbaldehyde
3-Pyridinecarboxaldehyde, 5-chloro-1,6-dihydro-6-oxo-
AKOS006230150
SY229656
5-chloro-6-oxo-1,6-dihydro-3-pyridinecarbaldehyde
AC-33380
3-Chloro-2-Hydroxy-5-Formylpyridine
MFCD04972384
627501-18-2
AKOS005072132
AMY7946
CS-0045266
5-Chloro-6-oxo-1,6-dihydropyridine-3-carbaldehyde
FGMJOLYLUIKTGP-UHFFFAOYSA-N
5-Chloro-6-hydroxynicotinaldehyde
3-Pyridinecarboxaldehyde,5-chloro-1,6-dihydro-6-oxo-
5-Chloro-6-hydroxypyridine-3-carboxaldehyde
5-Chloro-6-oxo-1,6-dihydro-3-pyridinecarbaldehyde
5-Chloro-1,6-dihydro-6-oxo-3-pyridinecarboxaldehyde
PubChem17091

MDL Number

MFCD04972384

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2)?

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) is a crystalline solid with a molecular weight of approximately 210.01 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive, particularly towards nucleophiles and bases, making it useful in various chemical transformations. It exhibits weak basicity and acidity, which can influence its reactivity in different synthetic contexts.

How is 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) typically synthesized?

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) can be synthesized through the condensation of 5-chloro-6-hydroxy-pyridine with acetaldehyde, often in the presence of a catalytic amount of acid. The reaction provides good yield and selectivity, with the use of common reagents like sulfuric acid or hydrochloric acid facilitating the process.

What industries use 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2)?

5-Chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2) is primarily used in the pharmaceutical and chemical industries for the development of intermediate compounds. It finds applications in the synthesis of drugs and other organic molecules due to its functional groups, which can be further modified to create various chemical entities.

What precautions should be taken when handling 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2)?

When handling 5-chloro-6-hydroxy-pyridine-3-carbaldehyde (CAS: 627501-18-2), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, well-ventilated area, and handled under a fume hood to minimize inhalation risk. In case of spills, immediate cleanup should be performed following standard laboratory safety procedures, and a Material Safety Data Sheet (MSDS) should be readily available for reference.