1H-Imidazo[4,5-c]pyridine(CAS: 272-97-9)

1H-Imidazo[4,5-c]pyridine is a crystalline solid with a molecular weight of approximately 153.15 g/mol. It shows moderate solubility in common organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions. It is generally soluble in polar aprotic solvents and slightly soluble in water.

1H-Imidazo[4,5-c]pyridine is typically synthesized via the condensation of 1H-imidazole and 2-pyridinemethanol. Common methods include the use of acetic acid as a solvent with heating, or using sodium hydride as a base. The reaction is known to have good yield, with selectivity towards the desired product.

1H-Imidazo[4,5-c]pyridine is used in various industries. It is a key component in the synthesis of pharmaceuticals due to its potential as an antiviral agent. It also finds applications in the development of sensors, semiconductors, and as a precursor in the polymer industry for the creation of functional materials.

When handling 1H-Imidazo[4,5-c]pyridine, it is crucial to wear appropriate personal protective equipment (PPE), including gloves and goggles. The compound should be stored in a cool, dry place, away from heat and ignition sources. In case of a spill, it should be cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed safety information.