1,3-Benzothiazole-6-sulfonyl chloride(CAS: 181124-40-3)

1,3-Benzothiazole-6-sulfonyl chloride is a crystalline solid with a molecular weight of approximately 231.19 g/mol. It is soluble in organic solvents like dichloromethane and ethyl acetate. This compound displays moderate reactivity, particularly in nucleophilic substitution reactions. It has low water solubility, making it suitable for organic synthesis applications.

1,3-Benzothiazole-6-sulfonyl chloride is commonly synthesized through the chlorosulfonation of 1,3-benzothiazole in the presence of concentrated sulfuric acid. The reaction is carried out at elevated temperatures, typically around 100°C, with high selectivity and moderate yield (around 70-80%).

1,3-Benzothiazole-6-sulfonyl chloride finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also used in the polymer industry as a stabilizer and in the production of conductive polymers. Additionally, it has applications in the development of sensors and in the electronics industry for its ability to form stable complexes.

When handling 1,3-Benzothiazole-6-sulfonyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be stored in a well-ventilated area, preferably in a fume hood. In case of a spill, it is recommended to use absorbent materials and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.