Ethyl 2-(4-formyl-2-nitrophenoxy)acetate(CAS: 420786-61-4)

Ethyl 2-(4-formyl-2-nitrophenoxy)acetate is a crystalline compound with a molecular weight of approximately 282.07 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound is reactive towards nucleophiles and oxidants, making it useful in organic synthesis. It exhibits weak acidity and can undergo electrophilic substitution reactions.

Ethyl 2-(4-formyl-2-nitrophenoxy)acetate can be synthesized by the condensation of 2-nitrophenol with ethyl acetoacetate in the presence of a catalyst, such as p-toluenesulfonic acid. The reaction is typically conducted under mild conditions, and the yield can be up to 70%. Selectivity towards the desired product is good, and the reaction is relatively straightforward.

Ethyl 2-(4-formyl-2-nitrophenoxy)acetate is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It also finds applications in the polymer industry for the development of functional polymers, and in the sensor industry for the fabrication of gas sensors. The compound's unique chemical properties make it valuable in these fields.

When handling Ethyl 2-(4-formyl-2-nitrophenoxy)acetate, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to airborne particles. Spills should be cleaned up immediately using appropriate absorbent materials, and proper waste disposal procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.