(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)propanoic acid(CAS: 1290040-14-0)

The compound (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)propanoic acid is a crystalline solid with a molecular weight of approximately 479.5 g/mol. Its solubility in water is low, and it is moderately soluble in organic solvents like DMSO. The compound is reactive towards nucleophilic attack, particularly at the amino and carboxylic acid functionalities. It is stable under normal temperature and pressure conditions but should be stored in a cool, dry place to maintain its structural integrity.

The compound is typically synthesized via a multi-step synthesis involving the formation of an amide through the coupling of a fluoren-9-yl methoxy carbonyl derivative with an indole-3-carboxylic acid. The use of appropriate catalysts such as HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base like DIPEA (N,N-diisopropylethylamine) is crucial for achieving high selectivity and yield. The final product is purified by recrystallization or HPLC.

This compound finds applications in the pharmaceutical industry, specifically in the development of novel pharmaceuticals with potential therapeutic effects. It is also used in the chemical industry, particularly in the synthesis of advanced organic materials and in the development of sensors and semiconductors. Its unique structural features make it a valuable intermediate in these fields.

When handling this compound, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Ensure that the work is conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed information on storage, emergency procedures, and disposal methods.