1-(4-Pyridinyl)-1-propanamine(CAS: 60289-68-1)

1-(4-Pyridinyl)-1-propanamine is a colorless liquid with a molecular weight of 145.19 g/mol. It has a pKa of approximately 7.5 and is moderately soluble in water. The compound is not highly reactive but shows basic properties due to the amine group. It has a boiling point of 198°C and a melting point of -21°C. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

1-(4-Pyridinyl)-1-propanamine is typically synthesized via the reaction of 4-pyridyl chloride and 1-propanamine. The reaction is catalyzed by triethylamine and proceeds at room temperature. The yield is approximately 85%, and the product is isolated by recrystallization from ethanol. Other methods include direct amination of 4-pyridyl chloride using sodium hydroxide as a base.

1-(4-Pyridinyl)-1-propanamine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It also finds applications in the production of polymers, particularly those used in electronic and optical applications. The compound is also used in the development of sensors and as a component in some semiconductor materials.

When handling 1-(4-Pyridinyl)-1-propanamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, use appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further instructions. Always use a fume hood when performing operations involving the compound to minimize inhalation risks.