1-(4-Pyridinyl)-1-propanamine

Basic Information

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CAS Number

60289-68-1

Molecular Formula

C8H12N2

Molecular Weight

136.19 g/mol

Basic Physical Properties

Boiling Point

238.4±15.0 ºC (760 Torr),

Density

0.998±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

118.6±7.4 ºC,

Vapor Pressure

0.0±0.5 mmHg at 25°C

SMILES

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CCC(C1=CC=NC=C1)N

InChI

InChI=1S/C8H12N2/c1-2-8(9)7-3-5-10-6-4-7/h3-6,8H,2,9H2,1H3

InChIKey

VGFZORUFTNLGLI-UHFFFAOYSA-N

LogP

1.4914

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

87.3

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Synonyms & References

English

SCHEMBL744414
EN300-84554
(1-PYRIDIN-4-YLPROPYL)AMINE
SB47390
SY011556
1-pyridin-4-ylpropan-1-amine
CS-0197312
A832673
1-(pyridin-4-yl)propan-1-amine
FT-0654759
1-(4-Pyridinyl)-1-propanamine
Z228583312
1-(4-Pyridyl)-1-propylamine
60289-68-1
AS-31840
DTXSID30597731
(1-Pyridin-4-ylpropyl)amine, AldrichCPR
AKOS009112499
1-PYRIDIN-4-YL-PROPYLAMINE
SB75667
MFCD06637477
AMY20033
1-pyridin-4-yl-1-propanamine
1-(Pyridin-4-yl)propan-1-amine
1-(4-BROMOPHENYL)CYCLOPENTANECARBONITRILE
(1-pyridin-4-ylpropyl)amine(SALTDATA: FREE)
CTK5B1253
MolPort-003-178-947
SBB069891
SureCN744414
1-(4-Pyridyl)-n-propylamine

MDL Number

MFCD06637477

FAQ

What are the physical and chemical properties of 1-(4-Pyridinyl)-1-propanamine (CAS: 60289-68-1)?

1-(4-Pyridinyl)-1-propanamine is a colorless liquid with a molecular weight of 145.19 g/mol. It has a pKa of approximately 7.5 and is moderately soluble in water. The compound is not highly reactive but shows basic properties due to the amine group. It has a boiling point of 198°C and a melting point of -21°C. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is 1-(4-Pyridinyl)-1-propanamine (CAS: 60289-68-1) typically synthesized?

1-(4-Pyridinyl)-1-propanamine is typically synthesized via the reaction of 4-pyridyl chloride and 1-propanamine. The reaction is catalyzed by triethylamine and proceeds at room temperature. The yield is approximately 85%, and the product is isolated by recrystallization from ethanol. Other methods include direct amination of 4-pyridyl chloride using sodium hydroxide as a base.

What industries use 1-(4-Pyridinyl)-1-propanamine (CAS: 60289-68-1)?

1-(4-Pyridinyl)-1-propanamine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It also finds applications in the production of polymers, particularly those used in electronic and optical applications. The compound is also used in the development of sensors and as a component in some semiconductor materials.

What precautions should be taken when handling 1-(4-Pyridinyl)-1-propanamine (CAS: 60289-68-1)?

When handling 1-(4-Pyridinyl)-1-propanamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, use appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further instructions. Always use a fume hood when performing operations involving the compound to minimize inhalation risks.