2-Aminoisonicotinonitrile(CAS: 42182-27-4)

2-Aminoisonicotinonitrile is a crystalline solid with a molecular weight of approximately 147.11 g/mol. It has a low solubility in water but is more soluble in organic solvents. Chemically, it is moderately reactive and can act as both an amine and a nitrile group. It is typically prepared by amidation and nitrile formation from other precursors.

2-Aminoisonicotinonitrile is usually synthesized through amidation of isonicotinoyl chloride with ammonia or an amine. The reaction is typically catalyzed by an acid or base, and yields are generally good. The process involves the formation of an amide bond followed by the introduction of a nitrile group.

2-Aminoisonicotinonitrile finds applications in pharmaceuticals, where it is used as a precursor for drug synthesis. It is also utilized in the production of dyes and pigments in the chemical industry. Additionally, it is employed in polymer synthesis and as a reagent in analytical chemistry for sensor development.

When handling 2-Aminoisonicotinonitrile, proper personal protective equipment (PPE) is essential, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be handled carefully using appropriate tools and materials. Always consult the Safety Data Sheet (SDS) for specific guidelines on handling and disposal.