2-Bromo-5-fluoroisonicotinic acid(CAS: 885588-12-5)

2-Bromo-5-fluoroisonicotinic acid is a crystalline solid with a molecular weight of approximately 243.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like dichloromethane. Chemically, it is moderately reactive, especially towards nucleophiles, and can undergo substitution reactions. It is also sensitive to moisture and air, making it necessary to store it in a desiccated and sealed container.

2-Bromo-5-fluoroisonicotinic acid is typically synthesized via electrophilic aromatic substitution of nicotinic acid. The reaction involves bromination of 5-fluoronicotinic acid with bromine in the presence of a catalyst like FeBr3. The yield and selectivity can be optimized by adjusting reaction conditions such as temperature and solvent choice.

2-Bromo-5-fluoroisonicotinic acid is primarily used in the pharmaceutical industry for the synthesis of intermediates and active pharmaceutical ingredients. It is also utilized in the chemical industry for preparing various functionalized derivatives for research and development purposes.

When handling 2-Bromo-5-fluoroisonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be stored in a fume hood and kept away from moisture and air. In case of a spill, it should be cleaned up using appropriate absorbent materials and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.