5-Methyl-2-(tributylstannyl)-1,3-thiazole(CAS: 848613-91-2)

5-Methyl-2-(tributylstannyl)-1,3-thiazole is a solid at room temperature, with a molecular weight of approximately 444.47 g/mol. It has a low solubility in water but good solubility in organic solvents like dichloromethane and toluene. Chemically, it exhibits poor reactivity under standard conditions, making it stable in air and moisture. Its crystalline form provides a stable structure, which is crucial for its intended applications in organic synthesis and material science.

5-Methyl-2-(tributylstannyl)-1,3-thiazole is synthesized via the coupling of tributyltin chloride with 1,3-thiazole-2-carbaldehyde in the presence of a Lewis acid catalyst, such as zinc chloride. The reaction is conducted at a moderate temperature, and the product is isolated by column chromatography. The selectivity and yield are influenced by the choice of catalyst and reaction conditions, with typical yields around 70-80%.

5-Methyl-2-(tributylstannyl)-1,3-thiazole is primarily used in the pharmaceutical and material science industries. It serves as a key intermediate in the synthesis of various drug candidates and is also employed in the development of organic electronic materials and sensors due to its unique chemical structure and reactivity.

When handling 5-Methyl-2-(tributylstannyl)-1,3-thiazole, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate solvents, and the area should be thoroughly ventilated. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal procedures.