(2S)-(2-Chlorophenyl)(hydroxy)acetic acid(CAS: 52950-19-3)

The physical and chemical properties of (2S)-(2-Chlorophenyl)(hydroxy)acetic acid include a white or off-white crystalline solid with a molecular weight of approximately 224.63 g/mol. It has a low solubility in water (0.4 g/100 mL at 25°C) and exhibits acidity due to the carboxylic acid group. The compound is reactive towards bases and can form salts. It is also susceptible to hydrolysis under basic conditions.

The synthesis of (2S)-(2-Chlorophenyl)(hydroxy)acetic acid typically involves the condensation of 2-chlorophenol with acetic anhydride, followed by hydrolysis to form the acetic acid derivative. Commonly, a strong base like sodium hydroxide is used in the hydrolysis step. The process requires careful control of pH and temperature to achieve high yields and selectivity.

The (2S)-(2-Chlorophenyl)(hydroxy)acetic acid (CAS: 52950-19-3) is utilized in the pharmaceutical industry for the synthesis of certain drugs due to its chemical structure. It is also employed in polymer synthesis as a monomer, and in the production of sensors and semiconductors for its ability to interact with specific chemical environments.

When handling (2S)-(2-Chlorophenyl)(hydroxy)acetic acid, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhaling vapors. Spills should be cleaned up using protective gear and proper spill kits. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.