Methyl 6-nitro-2-indolinecarboxylate(CAS: 428861-43-2)

Methyl 6-nitro-2-indolinecarboxylate (CAS: 428861-43-2) is a white crystalline solid with a molecular weight of approximately 221.08 g/mol. It is soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles. It is stable under neutral and slightly acidic conditions but can undergo hydrolysis under basic conditions.

Methyl 6-nitro-2-indolinecarboxylate (CAS: 428861-43-2) can be synthesized by the nitration of 2-indolinecarboxylic acid with concentrated nitric acid in the presence of a catalyst like sulfuric acid. The reaction is typically carried out at room temperature, and the product is purified by recrystallization from ethanol. The yield is generally around 80-85%.

Methyl 6-nitro-2-indolinecarboxylate (CAS: 428861-43-2) is primarily used in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also utilized in the preparation of materials for sensors and in some semiconductor applications due to its specific chemical properties.

When handling Methyl 6-nitro-2-indolinecarboxylate (CAS: 428861-43-2), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be carefully cleaned up using absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific safety guidelines.