2H-Chromene-3-carboxylic acid(CAS: 22649-28-1)

2H-Chromene-3-carboxylic acid (CAS: 22649-28-1) is a white crystalline solid with a molecular weight of approximately 188.14 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound is moderately reactive, particularly with bases, leading to the formation of sodium salts and other derivatives. It shows good stability under normal conditions but should be stored in a cool, dry place away from direct sunlight.

2H-Chromene-3-carboxylic acid is typically synthesized via the condensation of chromone with acetic anhydride followed by acid work-up. This method provides a good yield and selectivity. Other routes include the oxidation of chromene-3-aldehyde followed by acylation with an appropriate acid chloride. Catalysts such as hydrogen peroxide and sulfuric acid are commonly used to facilitate the oxidation step.

2H-Chromene-3-carboxylic acid (CAS: 22649-28-1) finds applications in various industries, particularly in pharmaceuticals, where it is used as a precursor in the synthesis of drugs. It is also utilized in the production of sensors and electronic materials, as well as in the development of certain polymers and semiconductors due to its favorable electronic and structural properties.

When handling 2H-Chromene-3-carboxylic acid (CAS: 22649-28-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. This compound can irritate the skin and eyes. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using proper spill kits and methods. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information and procedures.