1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

Basic Information

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CAS Number

183232-66-8

Molecular Formula

C22H21Cl2IN4O

Molecular Weight

555.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

196°C

Boiling Point

°Cat760mmHg

Solubility

Insuluble (5.2E-4 g/L) (25 ºC),

Refractive Index

1.702

SMILES

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CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I

InChI

InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChIKey

BUZAJRPLUGXRAB-UHFFFAOYSA-N

LogP

5.889820000000004

Topological Polar Surface Area

50.160000000000004 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

586

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

NCGC00025011-02
HMS1361M07
AM251
L000964
HMS2052K15
AM 251; AM-251
HMS3884H18
BML3-F08
IDI1_033995
SR-01000597360-6
HMS3267K22
HMS3676I21
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
AM-251
CBiol_001833
1h-pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-1-piperidinyl-
AM 251 (pharmaceutical)
KBio2_002813
Bio1_001097
Bio1_000608
183232-66-8
CS-3920
Bio2_000725
HY-15443
BRD-K92000912-001-02-7
KBioSS_000245
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
KBio3_000490
SR-01000597360
C20220
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide

MDL Number

MFCD01861181

FAQ

What are the physical and chemical properties of 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide (CAS: 183232-66-8)?

The compound is a crystalline solid with a molecular weight of approximately 621.3 g/mol. It has moderate solubility in common organic solvents like DMSO and methanol. Chemically, it is highly reactive, exhibiting typical amide and phenolic functionalities. It is stable under neutral and slightly acidic conditions but should be protected from strong acids and bases.

How is 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide (CAS: 183232-66-8) typically synthesized?

This compound is typically synthesized through multi-step organic synthesis involving the condensation of 2,4-dichlorophenyl and 4-iodophenyl groups with a piperidine derivative. The reaction involves the use of acyl chlorides and base catalysts, with careful control of reaction conditions to ensure high yield and selectivity.

What industries use 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide (CAS: 183232-66-8)?

This compound is primarily used in pharmaceutical research for its biological activity, specifically in the development of drugs targeting various diseases. It is also relevant in the polymer industry for its potential use in functional polymers and in the field of sensors for its sensing capabilities.

What precautions should be taken when handling 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide (CAS: 183232-66-8)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling this compound. Work should be conducted in a well-ventilated fume hood to minimize inhalation risk. Spills should be cleaned up promptly using appropriate absorbents, and the area should be thoroughly decontaminated. Safety data sheets (SDS) should be consulted for detailed handling and disposal procedures.