(3,4-Dimethoxyphenyl)boronic acid(CAS: 122775-35-3)

(3,4-Dimethoxyphenyl)boronic acid (CAS: 122775-35-3) is a white crystalline solid with a molecular weight of approximately 244.23 g/mol. It is moderately soluble in water and ethanol but has low solubility in nonpolar solvents. This compound is known for its reactivity in boronate ester formation and its ability to participate in Suzuki coupling reactions. It exhibits good stability under normal conditions but should be stored away from direct sunlight and moisture.

(3,4-Dimethoxyphenyl)boronic acid (CAS: 122775-35-3) can be synthesized using the Stille coupling reaction. Typically, 3,4-dimethoxyphenyl bromide is coupled with tetrakis(triphenylphosphine)palladium(0) and (trimethylsilyl)boron triflate in the presence of a base such as triethylamine. The reaction yields a high yield of the desired product with good regioselectivity and functional group compatibility.

(3,4-Dimethoxyphenyl)boronic acid (CAS: 122775-35-3) is widely used in the pharmaceutical industry for the synthesis of drug intermediates and in the electronics industry for the production of semiconductors. It also finds applications in the polymer industry for the synthesis of functional polymers and in the sensor industry for the development of chemical sensors due to its reactivity in boronate ester formation.

When handling (3,4-Dimethoxyphenyl)boronic acid (CAS: 122775-35-3), it is important to use proper personal protective equipment (PPE) such as gloves and goggles. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up using appropriate absorbent materials and the area should be well-ventilated. In case of skin contact, wash with water and seek medical advice. For detailed safety information, refer to the Material Safety Data Sheet (MSDS).