1-(3-Chloro-5-fluorophenyl)ethanone(CAS: 842140-52-7)

1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7) is a crystalline solid with a molecular weight of approximately 212.04 g/mol. The compound has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. It is mildly reactive and can undergo nucleophilic substitution and electrophilic aromatic substitution reactions.

1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7) is commonly synthesized via the reaction of 3-chloro-5-fluorophenylacetic acid with acetone in the presence of a suitable base like sodium hydride. The process involves a Claisen rearrangement followed by a dehydration step. The yield is typically around 70-80%, and the reaction is conducted under anhydrous conditions to avoid side reactions.

1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7) finds applications in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various drugs. It is also used in the polymer industry for the modification of polymer properties and in the sensor industry for the development of gas-sensing materials.

When handling 1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.