Compound Q&A
How is 1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7) typically synthesized?
Answer
1-(3-Chloro-5-fluorophenyl)ethanone (CAS: 842140-52-7) is commonly synthesized via the reaction of 3-chloro-5-fluorophenylacetic acid with acetone in the presence of a suitable base like sodium hydride. The process involves a Claisen rearrangement followed by a dehydration step. The yield is typically around 70-80%, and the reaction is conducted under anhydrous conditions to avoid side reactions.
About
CAS No
842140-52-7
English Name
1-(3-Chloro-5-fluorophenyl)ethanone
Molecular Formula
C8H6ClFO
Molecular Weight
172.59 g/mol
SMILES
CC(=O)c1cc(cc(c1)Cl)F
InChIKey
BVKHCVHYQNGCSC-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
