N2-Acetylguanine(CAS: 19962-37-9)

N2-Acetylguanine (CAS: 19962-37-9) is a crystalline compound with a molecular weight of approximately 198.18 g/mol. It has a solubility of about 25 mg/mL in water. Chemically, it is moderately reactive, particularly with bases and nucleophiles. It is stable under normal conditions but should be stored in a cool, dark place to avoid photodegradation.

N2-Acetylguanine can be synthesized by acetylating guanine in an organic solvent such as dichloromethane using acetic anhydride as the acetylating agent. The reaction is typically catalyzed by an acid like sulfuric acid, and the product is isolated by recrystallization. The yield is generally around 70-80%. Special attention should be given to proper handling of acetic anhydride and sulfuric acid due to their hazardous nature.

N2-Acetylguanine finds applications in the pharmaceutical industry as an intermediate in the synthesis of nucleoside drugs. It is also used in the chemical and biochemical research fields for studying DNA and RNA metabolism. Additionally, it has potential applications in the development of new materials and sensors.

When handling N2-Acetylguanine, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or under a fume hood to minimize exposure. Spills should be cleaned up carefully, and the area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.