2-Chloro-6-fluoro-4(1H)-quinazolinone(CAS: 769158-12-5)

2-Chloro-6-fluoro-4(1H)-quinazolinone is a crystalline solid with a molecular weight of approximately 237.04 g/mol. It has a low solubility in water but is soluble in polar organic solvents like DMSO and DMF. The compound is moderately reactive, showing some tendency to undergo substitution reactions. It decomposes above 200°C and is stable under normal laboratory conditions.

2-Chloro-6-fluoro-4(1H)-quinazolinone is typically synthesized via the condensation reaction of 6-fluoroquinazoline with thionyl chloride, followed by removal of the byproduct. This method provides good yield and selectivity. Alternatively, it can be prepared by the reaction of 6-fluoro-4-oxoquinazoline-3-carboxylic acid with chloroform followed by hydrolysis.

2-Chloro-6-fluoro-4(1H)-quinazolinone is primarily used in pharmaceutical research for its potential as an inhibitor of various enzymes. It also finds application in the development of novel materials, particularly in the field of sensors and semiconductors, due to its unique electronic properties.

When handling 2-Chloro-6-fluoro-4(1H)-quinazolinone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.