Compound Q&A
How is 2-Chloro-6-fluoro-4(1H)-quinazolinone (CAS: 769158-12-5) typically synthesized?
Answer
2-Chloro-6-fluoro-4(1H)-quinazolinone is typically synthesized via the condensation reaction of 6-fluoroquinazoline with thionyl chloride, followed by removal of the byproduct. This method provides good yield and selectivity. Alternatively, it can be prepared by the reaction of 6-fluoro-4-oxoquinazoline-3-carboxylic acid with chloroform followed by hydrolysis.
About
CAS No
769158-12-5
English Name
2-Chloro-6-fluoro-4(1H)-quinazolinone
Molecular Formula
C8H4ClFN2O
Molecular Weight
198.58 g/mol
SMILES
C1=CC2=C(C=C1F)C(=O)NC(=N2)Cl
InChIKey
CBHYEOLZQCLMSY-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
