2,3,6-Trichloro-5-(trifluoromethyl)pyridine(CAS: 80289-91-4)

2,3,6-Trichloro-5-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 308.03 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophilic reagents.

2,3,6-Trichloro-5-(trifluoromethyl)pyridine is commonly synthesized via electrophilic aromatic substitution. The reaction involves chlorination and trifluoromethylation of pyridine using appropriate reagents. Catalysts such as PCC (Pyridinium chlorochromate) are often used to achieve high selectivity and yield.

2,3,6-Trichloro-5-(trifluoromethyl)pyridine is used in various industries, including pharmaceuticals for the synthesis of certain drug candidates, and in the polymer and semiconductor industries for the development of functional materials and sensors.

When handling 2,3,6-Trichloro-5-(trifluoromethyl)pyridine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.