1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid(CAS: 113100-53-1)

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid has a crystalline form at room temperature. The molecular weight is approximately 232.07 g/mol. It is slightly soluble in water and has a pKa of about 3.7. The compound is relatively stable but can undergo hydrolysis under basic conditions. It is an organic acid with strong electron-withdrawing groups, making it a potent electrophile in organic synthesis.

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid can be synthesized via a multistep process. Common methods include the condensation of 3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde with methylamine followed by acid catalysis to form the carboxylic acid. This reaction is typically carried out with a catalyst such as hydrochloric acid or sulfuric acid, and yields can range from 70-85%. The process requires careful control of reaction conditions to achieve high selectivity and yield.

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid is used primarily in the pharmaceutical industry, where it serves as an intermediate for the synthesis of various drugs. It is also utilized in the polymer industry for the development of novel materials with unique properties. Additionally, this compound has applications in the production of sensors and semiconductors due to its electronic and chemical properties.

When handling 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, it is important to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a closed container away from moisture and heat sources. In case of a spill, it is advisable to use a fume hood and appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and disposal procedures.