Compound Q&A

How is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS: 113100-53-1) typically synthesized?

Answer

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid can be synthesized via a multistep process. Common methods include the condensation of 3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde with methylamine followed by acid catalysis to form the carboxylic acid. This reaction is typically carried out with a catalyst such as hydrochloric acid or sulfuric acid, and yields can range from 70-85%. The process requires careful control of reaction conditions to achieve high selectivity and yield.

About

English Name 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Molecular Formula C6H5F3N2O2
Molecular Weight 194.11 g/mol
SMILES CN1C=C(C(=N1)C(F)(F)F)C(=O)O
InChIKey FZNKJQNEJGXCJH-UHFFFAOYSA-N
Last Updated: 2025-09-28 13:06

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