Norvaline(CAS: 760-78-1)

Norvaline is a cyclic non-protein amino acid with a molecular formula of C7H14N2O2. It is a white crystalline powder with a bitter taste. Physicochemical properties include a solubility of 71 mg/mL in water and 1.7 mg/mL in ethanol. Chemically, it is relatively stable but can react with strong bases. Its molecular weight is 150.22 g/mol.

Norvaline can be synthesized through a sequence of reactions starting from valine. Common methods include a condensation of valine with a suitable acylating agent in the presence of a catalyst like a Lewis acid, followed by deprotection and cyclization. The overall yield is moderate, around 50-60%, with high selectivity for the desired product.

Norvaline is primarily used in the pharmaceutical industry for the development of specific drugs. It is also used in the food industry as a flavor enhancer and in the polymer industry as a monomer for certain polymers. Additionally, it has applications in sensors and semiconductors due to its unique structural characteristics.

Handling Norvaline requires care due to its chemical nature. Always wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store in a cool, dry place away from direct sunlight and heat sources. In case of spillage, neutralize with a suitable acid or base and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.