Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride (1:1)(CAS: 874964-22-4)

Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride is a white crystalline solid with a molecular weight of approximately 223.7 g/mol. It has a solubility of about 10 g/L in water and is slightly soluble in ethanol. The compound is reactive, particularly towards bases, and is used in various applications due to its chiral structure. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride is synthesized by the reaction of (S)-3-methylpyrrolidine with acetic anhydride followed by hydrolysis with hydrochloric acid. The reaction is typically carried out in anhydrous conditions to minimize side reactions. The yield is around 85-90%, and the use of suitable catalysts can improve selectivity and efficiency.

Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various chiral compounds, which are essential for drug development. The compound is also utilized in the production of polymers, sensors, and as a chiral auxiliary in organic synthesis.

When handling Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of dust. In the case of spills, they should be cleaned up immediately using appropriate absorbents. Safety data sheets (SDS) should be consulted for detailed information on handling and storage recommendations. The compound should be stored in a cool, dry place away from direct sunlight and heat sources.