2-Fluoro-4-iodobenzonitrile(CAS: 137553-42-5)

2-Fluoro-4-iodobenzonitrile is a crystalline solid with a molecular weight of approximately 287.03 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. This compound is known for its low reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions under appropriate conditions.

2-Fluoro-4-iodobenzonitrile is typically synthesized via the Suzuki-Miyaura coupling reaction between 2-fluorobromobenzene and iodobenzene in the presence of a palladium catalyst, such as tetrakis(triphenylphosphine)palladium(0), and a base like sodium carbonate. The yield and selectivity can be improved by optimizing the reaction conditions.

2-Fluoro-4-iodobenzonitrile is used in the pharmaceutical industry for the synthesis of certain medicinal compounds due to its unique chemical structure. It may also find applications in the polymer industry for developing advanced materials, and in the sensor industry for creating chemical sensors due to its reactivity.

When handling 2-Fluoro-4-iodobenzonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated fume hood to minimize exposure. In case of a spill, immediately clean up the area using appropriate absorbent materials and consult the safety data sheet (SDS) for further instructions.