Compound Q&A
How is 2-Fluoro-4-iodobenzonitrile (CAS: 137553-42-5) typically synthesized?
Answer
2-Fluoro-4-iodobenzonitrile is typically synthesized via the Suzuki-Miyaura coupling reaction between 2-fluorobromobenzene and iodobenzene in the presence of a palladium catalyst, such as tetrakis(triphenylphosphine)palladium(0), and a base like sodium carbonate. The yield and selectivity can be improved by optimizing the reaction conditions.
About
CAS No
137553-42-5
English Name
2-Fluoro-4-iodobenzonitrile
Molecular Formula
C7H3FIN
Molecular Weight
236.03 g/mol
SMILES
C1=CC(=C(C=C1I)F)C#N
InChIKey
WHQVXHBSTRFRCE-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
