2-Amino-6-bromobenzoic acid(CAS: 20776-48-1)

2-Amino-6-bromobenzoic acid is a crystalline solid with a molecular weight of approximately 267.02 g/mol. It has a low solubility in water (0.1 g/100 mL at 20°C) and exhibits typical reactivity of carboxylic acids and amines. It is moderately acidic and can undergo substitution reactions in the presence of amines and nucleophiles.

2-Amino-6-bromobenzoic acid can be synthesized via bromination of 2-aminobenzoic acid followed by purification. Commonly, bromine in acetone is used as the brominating agent. The reaction is selective and yields a high percentage of the target compound. Additionally, catalytic hydrogenation of 2-bromo-6-nitrobenzoic acid can also produce this compound.

2-Amino-6-bromobenzoic acid finds applications in pharmaceuticals, particularly in the development of organic dyes and pigments for colorimetric sensors. It is also used in the synthesis of certain azo dyes and as an intermediate in the production of various polymers and semiconductor materials.

When handling 2-Amino-6-bromobenzoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be handled with caution, using appropriate cleanup procedures, and the substance should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.