[D-Trp7,9,10]-Substance P(CAS: 89430-38-6)

[D-Trp7,9,10]-Substance P (CAS: 89430-38-6) is a crystalline peptide with a molecular weight of approximately 1,072 Da. It is sparingly soluble in water and has a pKa of around 8.5. This compound exhibits high reactivity with carboxypeptidase A and is stable under normal storage conditions but degrades under alkaline conditions.

[D-Trp7,9,10]-Substance P (CAS: 89430-38-6) is synthesized via solid-phase peptide synthesis using Fmoc chemistry. Commonly, the peptide is assembled using a 9-fluorenylmethoxycarbonyl (Fmoc) strategy, with selective deprotection and coupling steps. The final product is then cleaved from the resin using trifluoroacetic acid (TFA) and purified by HPLC or other chromatographic methods.

[D-Trp7,9,10]-Substance P (CAS: 89430-38-6) is primarily used in the pharmaceutical industry for research and development of analgesic and anti-inflammatory drugs. It is also utilized in the biochemical and biotechnology sectors for studying receptor binding and signaling pathways. Additionally, this compound may have applications in the sensor and semiconductor industries due to its unique physicochemical properties.

When handling [D-Trp7,9,10]-Substance P (CAS: 89430-38-6), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work within a fume hood to minimize inhalation risks. Spills should be cleaned up with caution, using absorbent materials, and disposing of waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling procedures and emergency response guidelines.