Compound Q&A
How is [D-Trp7,9,10]-Substance P (CAS: 89430-38-6) typically synthesized?
Answer
![[D-Trp7,9,10]-Substance P](https://static.chemtradehub.com/structs/894/89430-38-6-0fbe.webp "[D-Trp7,9,10]-Substance P")
[D-Trp7,9,10]-Substance P (CAS: 89430-38-6) is synthesized via solid-phase peptide synthesis using Fmoc chemistry. Commonly, the peptide is assembled using a 9-fluorenylmethoxycarbonyl (Fmoc) strategy, with selective deprotection and coupling steps. The final product is then cleaved from the resin using trifluoroacetic acid (TFA) and purified by HPLC or other chromatographic methods.
About
CAS No
89430-38-6
English Name
[D-Trp7,9,10]-Substance P
Molecular Formula
C79H105N21O13S
Molecular Weight
1588.88 g/mol
SMILES
CSCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CC6=CNC7=CC=CC=C76)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C9CCCN9C(=O)C(CCCNC(=N)N)N
InChIKey
ZDXXOQXJCDHSRG-GGDSLUOHSA-N
Last Updated: 2026-01-07 10:17