Acetildenafil-d8(CAS: 1189944-10-2)

Acetildenafil-d8 is a crystalline compound with a molecular weight of approximately 470.45 g/mol. It is slightly soluble in water and highly soluble in organic solvents like DMSO. It has a stable structure under normal laboratory conditions but reacts with strong bases. Its stable crystalline form allows it to be stored at room temperature away from moisture and heat.

Acetildenafil-d8 is synthesized via a multi-step process starting from sildenafil and acetate. The reaction typically requires a strong base like sodium hydride and proceeds in an anhydrous solvent. The product is isolated by filtration and recrystallization to obtain the pure crystalline form. The yield is around 70%, and the reaction is highly selective.

Acetildenafil-d8 is primarily used in the pharmaceutical industry for research and development purposes due to its structural similarity to sildenafil. It is also of interest in the analytical chemistry field for its derivative formation capability, which can be used in various sensing applications.

Proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be done in a fume hood to minimize inhalation risks. Spills should be handled by immediately containing them with absorbent materials and disposing of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.