3-chloro-1H-pyrrolo[2,3-b]pyridine(CAS: 80235-01-4)

3-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 80235-01-4) is a crystalline solid with a molecular weight of approximately 169.57 g/mol. It is slightly soluble in water and has good solubility in organic solvents like methanol and acetonitrile. The compound exhibits basic properties and is moderately reactive, particularly towards nucleophiles. It can be produced by electrophilic chlorination of pyrrolo[2,3-b]pyridine.

3-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 80235-01-4) is synthesized by electrophilic chlorination of pyrrolo[2,3-b]pyridine using chlorine gas as the chlorinating agent. The reaction typically occurs under anhydrous conditions in the presence of a Lewis acid catalyst such as aluminum chloride. The yield is around 70-80% with good selectivity for the desired product.

3-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 80235-01-4) finds applications in the pharmaceutical industry as an intermediate for synthesizing various bioactive compounds. It is also used in the electronics industry for the production of semiconductors and organic light-emitting diodes (OLEDs), and in the polymer industry for the synthesis of functional polymers with specific properties.

When handling 3-chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 80235-01-4), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area and handled in a fume hood. In case of spill, immediately clean up the area and refer to the safety data sheet (SDS) for specific cleanup procedures. Avoid contact with skin and eyes, and ensure proper disposal according to local regulations.