2-Chloro-3-(trifluoromethyl)benzaldehyde(CAS: 93118-03-7)

2-Chloro-3-(trifluoromethyl)benzaldehyde is a crystalline compound with a molecular weight of 266.01 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive, showing electrophilic aromatic substitution and aldehyde chemistry. It has a melting point of 107-108°C and a boiling point of 245-247°C. The compound is non-flammable and has a low vapor pressure.

2-Chloro-3-(trifluoromethyl)benzaldehyde can be synthesized via the acylation of 3-(trifluoromethyl)benzaldehyde with chloroacetyl chloride in the presence of a base like triethylamine. This reaction is carried out in anhydrous dichloromethane or hexane. The yield is typically around 75-85%, and the reaction is selective and generates the desired product with high purity.

2-Chloro-3-(trifluoromethyl)benzaldehyde is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the production of functional polymers and as a precursor in the development of sensors and semiconductors. The compound is a key intermediate in the chemical industry due to its unique chemical properties.

When handling 2-Chloro-3-(trifluoromethyl)benzaldehyde, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. A Material Safety Data Sheet (MSDS) should be readily available for reference.