Methyl 2,6-dichloro-4-pyrimidinecarboxylate(CAS: 6299-85-0)

Methyl 2,6-dichloro-4-pyrimidinecarboxylate (CAS: 6299-85-0) is a white crystalline solid with a molecular weight of 266.02 g/mol. It has low water solubility and is soluble in organic solvents like methanol and acetonitrile. It is moderately reactive, particularly with nucleophiles and reducing agents.

Methyl 2,6-dichloro-4-pyrimidinecarboxylate (CAS: 6299-85-0) is typically synthesized via the condensation of methyl acetoacetate with 2,6-dichloropyrimidine, using a base like sodium hydroxide. The reaction is performed in an aprotic solvent such as dimethylformamide (DMF). The yield is around 70-80% with high selectivity.

Methyl 2,6-dichloro-4-pyrimidinecarboxylate (CAS: 6299-85-0) is primarily used in the pharmaceutical industry for the synthesis of various pyrimidine-based drugs. It also has applications in the polymer industry for developing novel materials with specific properties. Additionally, it is utilized in the synthesis of analytical reagents and as a precursor in sensor development.

When handling Methyl 2,6-dichloro-4-pyrimidinecarboxylate (CAS: 6299-85-0), appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. The material should be handled in a well-ventilated area or a fume hood. In the event of a spill, it should be carefully cleaned up with appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed information on handling and disposal.