3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole(CAS: 832114-00-8)

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole is a white crystalline solid with a molecular weight of approximately 312.3 g/mol. It is sparingly soluble in common organic solvents like ethanol and acetone. The compound shows moderate reactivity in the presence of moisture and is susceptible to hydrolysis. It is stable under anhydrous conditions.

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole is typically synthesized via a metal-catalyzed coupling reaction, often using Pd(0) catalysts like Pd(PPh3)4. The reaction involves the coupling of a boronic acid derivative with a 1,2-oxazole derivative under an inert atmosphere, yielding the target compound with good selectivity and up to 90% yield.

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole is used in the pharmaceutical industry for drug synthesis, particularly in the development of boron-containing drugs. It is also relevant in the polymer industry for introducing boron functionality into polymers, and in the electronics industry for the production of semiconductors and sensors.

When handling 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be stored in a cool, dry place away from moisture. In case of spill, use an appropriate spill kit or dry it with absorbent material. Refer to the safety data sheet (SDS) for detailed information on handling and disposal.