1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine(CAS: 1323919-64-7)

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine is a white crystalline solid with a molecular weight of approximately 438.47 g/mol. It is slightly soluble in water and more soluble in organic solvents like DMSO. The compound is reactive towards nucleophiles and readily undergoes substitution reactions.

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine is commonly synthesized via a multi-step process involving the coupling of a pyrazole derivative with 1-methylpiperidine in the presence of a borate ester and a palladium catalyst. The reaction is typically carried out under standard conditions of temperature and pressure with high selectivity and yield.

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also applied in the chemical and materials industry for the development of novel materials with specific properties.

When handling 1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. The compound should be handled in a well-ventilated area or a fume hood. In case of a spill, immediately clean up using the appropriate spill kit and follow safety protocols. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.