5-Chloro-1H-pyrrolo[3,2-b]pyridine(CAS: 65156-94-7)

5-Chloro-1H-pyrrolo[3,2-b]pyridine is a crystalline solid with a molecular weight of approximately 203.56 g/mol. It has poor water solubility but is soluble in common organic solvents like ethanol and DMSO. This compound exhibits moderate reactivity, particularly towards nucleophiles and electrophiles, making it suitable for various synthetic transformations.

5-Chloro-1H-pyrrolo[3,2-b]pyridine is commonly synthesized via the condensation of 2-chloropyridine with 1,2-dichloropyrrole in the presence of a base such as potassium carbonate. The reaction typically provides high yield and good selectivity, though careful control of reaction conditions is necessary to achieve optimal results.

5-Chloro-1H-pyrrolo[3,2-b]pyridine is used in the pharmaceutical industry for the synthesis of certain drug candidates due to its pharmacological properties. It is also employed in the polymer industry for the development of novel materials, and in the semiconductor industry for its use in thin film deposition processes and as a dopant.

When handling 5-Chloro-1H-pyrrolo[3,2-b]pyridine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and proper disposal methods. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.