5-Chloro-1H-pyrrolo[3,2-b]pyridine

Basic Information

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CAS Number

65156-94-7

Molecular Formula

C7H5ClN2

Molecular Weight

152.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

304.9 °C at 760 mmHg

Density

1.425

Flash Point

166.8 °C

Refractive Index

1.703

SMILES

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C1=CC(=NC2=C1NC=C2)Cl

InChI

InChI=1S/C7H5ClN2/c8-7-2-1-5-6(10-7)3-4-9-5/h1-4,9H

InChIKey

RFPQVCYUKAYKEG-UHFFFAOYSA-N

LogP

2.2162999999999995

Topological Polar Surface Area

28.68 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

129

Safety Information

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GHS Hazard Pictograms

H302

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AKOS005258070
5-Chloro-1H-pyrrolo [3,2-b]pyridine
BCP26427
65156-94-7
1H-Pyrrolo[3,2-b]pyridine, 5-chloro-
RFPQVCYUKAYKEG-UHFFFAOYSA-N
FT-0647229
PB26323
A8855
J-517258
5-Chloro-1H-pyrrolo[3,2-b]pyridine
5-chloropyrrolo-[3,2-b]pyridine
DTXSID00495654
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE
5-Chloro-1H-pyrrolo[3,2-b]pyridine, AldrichCPR
5-chloro-1H-pyrrolo[3,2-b]pyridine;5-Chloro-4-azaindole
DS-12093
SY030375
AM20061747
SCHEMBL421423
MFCD08062553
CS-W008284
J-514892
5-Chloro-4-azaindole
1H-Pyrrolo[3,2-beta]pyridine,5-chloro-
zlchem 923
PubChem16928
5-Chloro-4- Azaindole
HIN1489
ZLD0387
BBL101232

MDL Number

MFCD08062553

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 65156-94-7)?

5-Chloro-1H-pyrrolo[3,2-b]pyridine is a crystalline solid with a molecular weight of approximately 203.56 g/mol. It has poor water solubility but is soluble in common organic solvents like ethanol and DMSO. This compound exhibits moderate reactivity, particularly towards nucleophiles and electrophiles, making it suitable for various synthetic transformations.

How is 5-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 65156-94-7) typically synthesized?

5-Chloro-1H-pyrrolo[3,2-b]pyridine is commonly synthesized via the condensation of 2-chloropyridine with 1,2-dichloropyrrole in the presence of a base such as potassium carbonate. The reaction typically provides high yield and good selectivity, though careful control of reaction conditions is necessary to achieve optimal results.

What industries use 5-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 65156-94-7)?

5-Chloro-1H-pyrrolo[3,2-b]pyridine is used in the pharmaceutical industry for the synthesis of certain drug candidates due to its pharmacological properties. It is also employed in the polymer industry for the development of novel materials, and in the semiconductor industry for its use in thin film deposition processes and as a dopant.

What precautions should be taken when handling 5-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 65156-94-7)?

When handling 5-Chloro-1H-pyrrolo[3,2-b]pyridine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and proper disposal methods. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.