1-Methoxy-3-methylbenzene(CAS: 100-84-5)

1-Methoxy-3-methylbenzene (CAS: 100-84-5) is a colorless, crystalline solid with a molecular weight of 130.19 g/mol. It has a melting point of 45-46°C and a boiling point of 268-270°C. This compound is slightly soluble in water but soluble in common organic solvents such as ethanol, acetone, and chloroform. Chemically, it is less reactive compared to other aromatic compounds but can undergo electrophilic substitution reactions under appropriate conditions.

1-Methoxy-3-methylbenzene can be synthesized via the Friedel-Crafts acylation of 3-methylbenzene with methanol in the presence of a Lewis acid catalyst, such as aluminum trichloride (AlCl3). The reaction yields the desired product with good selectivity and moderate yield, although the exact yield depends on the reaction conditions and catalyst used.

1-Methoxy-3-methylbenzene (CAS: 100-84-5) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, where it can be used to produce nonsteroidal anti-inflammatory drugs (NSAIDs). In the polymer industry, it serves as a monomer for certain types of resins. Additionally, it has applications in the production of sensors and semiconductors due to its aromatic structure.

When handling 1-Methoxy-3-methylbenzene (CAS: 100-84-5), handle with care in a well-ventilated area or fume hood. Wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the storage area is cool and dry. In case of a spill, use appropriate absorbents and follow proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.