methyl 6-cyano-1H-indole-2-carboxylate(CAS: 104291-83-0)

Methyl 6-cyano-1H-indole-2-carboxylate (CAS: 104291-83-0) is a solid with a crystalline form. It has a molecular weight of approximately 229.21 g/mol. This compound is slightly soluble in water but soluble in common organic solvents like ethanol and dichloromethane. It is known for its reactivity towards nucleophiles and electrophiles, making it useful in various synthetic applications.

Methyl 6-cyano-1H-indole-2-carboxylate (CAS: 104291-83-0) is typically synthesized via a multistep process involving the condensation of indole-2-carboxylic acid and cyanoacetamide, followed by esterification with methanol. This reaction can be catalyzed by various Lewis acids or reactive metal catalysts. The yield is typically around 70-80%.

Methyl 6-cyano-1H-indole-2-carboxylate (CAS: 104291-83-0) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various medications and is also utilized in the development of new materials such as polymers and sensors due to its unique chemical functionality.

When handling methyl 6-cyano-1H-indole-2-carboxylate (CAS: 104291-83-0), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhaling the vapors. Spills should be handled with appropriate absorbent materials, and the material safety data sheet (MSDS) should be consulted for detailed spill cleanup procedures.