(4-Cyano-3-methoxyphenyl)boronic acid(CAS: 677777-45-6)

(4-Cyano-3-methoxyphenyl)boronic acid is a white crystalline solid with a molecular weight of approximately 256.17 g/mol. It is poorly soluble in water but soluble in common organic solvents like ethanol and acetone. The compound shows moderate reactivity, particularly in boron hydride reactions and in coupling reactions with halides under palladium catalysis.

(4-Cyano-3-methoxyphenyl)boronic acid is commonly synthesized through the arylation of (4-cyano-3-methoxyphenyl)boronic ester with sodium hydride in the presence of a palladium catalyst. The reaction typically yields a high purity product with good selectivity and moderate to high yield, depending on the specific conditions.

(4-Cyano-3-methoxyphenyl)boronic acid finds applications in the pharmaceutical industry for the synthesis of complex molecules, in the production of polymers for electronic and optical applications, and in the development of sensors for detecting various analytes. It is also used in semiconductor manufacturing due to its ability to participate in cross-coupling reactions.

When handling (4-Cyano-3-methoxyphenyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated fume hood to minimize inhalation risk. Spills should be immediately cleaned up with appropriate absorbent materials, and proper disposal methods should be followed as per the safety data sheet (SDS).