5-(Chloromethyl)-1H-tetrazole(CAS: 55408-11-2)

5-(Chloromethyl)-1H-tetrazole (CAS: 55408-11-2) is a crystalline compound with a molecular weight of approximately 142.54 g/mol. It is sparingly soluble in water but soluble in organic solvents like methanol and ethanol. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

5-(Chloromethyl)-1H-tetrazole (CAS: 55408-11-2) is typically synthesized by reacting chloromethyl ketone with hydrazine hydrate in the presence of an acid catalyst such as hydrochloric acid. The reaction involves condensation to form the tetrazole ring, with a yield of around 70-80%. The method is selective and efficient, making it a preferred route for industrial production.

5-(Chloromethyl)-1H-tetrazole (CAS: 55408-11-2) is mainly used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds applications in the polymer industry for modifying polymers, and in the sensor industry for the development of gas sensors. Its reactivity makes it valuable in semiconductor manufacturing for etching and other processes.

When handling 5-(Chloromethyl)-1H-tetrazole (CAS: 55408-11-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or in a fume hood to minimize exposure. Spills should be cleaned up immediately with the appropriate absorbent material, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.