4,6-Bis[3,5-di(2-pyridinyl)phenyl]-2-methylpyrimidine(CAS: 1266181-51-4)

4,6-Bis[3,5-di(2-pyridinyl)phenyl]-2-methylpyrimidine is a crystalline solid with a molecular weight of approximately 636.4 g/mol. It is poorly soluble in water but soluble in organic solvents like DMF, DMSO, and acetonitrile. Chemically, it exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It does not react readily with electrophiles, making it suitable for various synthetic applications.

4,6-Bis[3,5-di(2-pyridinyl)phenyl]-2-methylpyrimidine can be synthesized via a multistep process involving the condensation of 2-pyridine carboxaldehyde with 3,5-di(2-pyridinyl)phenylisocyanate followed by the reaction with 2-methylpyrimidine. This process involves the use of catalysts such as 4-dimethylaminopyridine (DMAP) and typically yields the compound with high selectivity and good purity.

4,6-Bis[3,5-di(2-pyridinyl)phenyl]-2-methylpyrimidine is primarily used in the pharmaceutical industry for developing antiviral and anticancer drugs due to its unique chemical structure. It also finds applications in the polymer industry for its potential as a monomer and in the sensor technology for its sensing capabilities.

When handling 4,6-Bis[3,5-di(2-pyridinyl)phenyl]-2-methylpyrimidine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. It is advisable to refer to the safety data sheet (SDS) for detailed handling and disposal instructions.